的司夜刺客。 与 会快速削减美杜莎的法力值。 不会打断 并且依然会石化面向美杜莎的单位（通常是释放星体禁锢的殁境神蚀者自己），但是这会阻止美杜莎寻找一个良好的输出环境进行输出。 是一个广范围的法力燃烧爆炸，如果击中美杜莎的法力护盾会因为高伤害而燃烧美杜莎更多的法力值。 会对美杜莎施加缴械状态从而无法在团战中造成范围物理输出。 可以使敌方队伍对美杜莎造成高频率的短暂眩晕，从而阻止她释放她的大招（拥有很长的施法前摇）。
的英雄也会使美杜莎变得脆弱，比如 , ,
会快速烧掉美杜莎用于法力护盾的法力值。 会召唤具有法力燃烧能力的随从，同时美杜莎也很容易受到遗愿的伤害。 的缴械对美杜莎的分裂箭极为有效。
- Medusa's Split shot allows her to focus on killing the tombstone while still dealing damage to the enemy heroes, or simply ignore the tombstone and allow her split shot to prevent the zombies from building up.
- Mana shield effectively counters Reaper's Scythe, as it can tank 60% of the damage. With sufficient mana, Medusa can survive the Scythe at 19%/22%/24%.
- Heartstopper Aura does not chip away at Medusa's mana.
- Necrophos has a movement speed equal to Medusa, and is easy to chase down with a slowing item in Medusa's inventory.
- Enchantress often has a small army of neutral creeps, allowing Medusa to hit her with a later bounce of her Mystic Snake.
- Enchantress passive Untouchable is easily avoided by Medusa. Simply target another enemy hero or creep, and let split shot hit her.
- Medusa is one of Sven's primal counter since he relies on man-fighting which is prevented and kited with stone gaze
- Also has a small mana pool and mystic snake does pure damage while a unit is petrified, a minor buff that is useful in case he used warcry
- A farmed Medusa will be a very hard kill for Sven forcing him to go on others while she chips away at him, usually building Eye of Skadi will leave Sven very slow and soon dead
- Completely negates the burst damage from the shotgun build as mana shield blocks all damage before reductions
- Another example, mana shield negates all damage before reductions meaning that Corrosive Haze won't do much unless Medusa is completely out of mana
- A very immobile hero very likely to Sven, making Medusa hard to catch or even use your Open Wounds on her as a Medusa will almost always go Linkens Sphere, making Lifestealer an easy target for Stone Gaze
- Heroes that rely on illusions to deal damage will find their illusions destroyed by Stone Gaze and Split Shot:
- Heroes that rely on summons. A few strong summons, such as with Lycan or allow Medusa to bounce her Mystic Snake between them to hit the hero for additional damage. Many weak summons, such as Broodmother or Lycan, force the group to tank Medusa's split shot.
- Heroes that rely on BKB to survive teamfights.
- In theory Medusa counters all Melee heroes, even though that is not the case with Mana-burning heroes and heroes with escapes, Medusa can outfight even AM if he gets petrified so by all means Medusa should be feared
- Deals area damage with ultimate and can stun/disable to cast Stone Gaze and make it easier to freeze enemy heroes.
- Berserker's Call can force enemies to face Medusa during her Stone Gaze.
- Lua错误 模块:Ability_ID的第48行：无法找到"精准光环"的Cargo数据
amplifies Medusa's Split Shot.
- Drow Ranger's midgame strength allows Medusa to farm safely, then take the lead once Drow Ranger's relative strength drops in the late game.
- During teamfights, casting Disruption upon Medusa creates a pair of illusions with Split Shot and 80% of her base damage.
- Shadow Demon can stack 2-3 jungle camps at the same time, speeding up Medusa's farming phase.
- Stoned enemies are immune to magical damage, but Shadow Poison can still build stacks during the Stoned phase.
- Witch Doctor's ultimate deals physical damage, so if Medusa managed to petrify a bunch of enemies with the given physical damage bonus, Death Ward can shred through enemies especially with Aghanim's Scepter
- Heroes that deal pure damage like Tinker's Aghanim Laser upgrade can give him enough time to cast it a couple of times or Outworld Devourer can deal the full damage of his Arcane Orb and stack a lot of intelligence for those 3 seconds of Stone Gaze
- Everyone with good physical damage and lock down for a good Stone Gaze
- Abilities that grant sustain or heroes with sustain to keep the enemy kited and distracted while Medusa slowly destroys them